דרישות קדם: ביוכימיה ב׳

 

סוג הקורס: שיעור + תרגול

 

1.Introduction to protein structure


2.Physical methods for determining the structure of proteins


3.3D structure visualization and analysis.


4.Structure comparison and superposition.


5.Protein classification and evolution.


6.Molecular maps, surface properties, conservation.


7.Structure prediction.


8.Structure-based function prediction


9.Enzyme active sites and protein–small molecule interactions.


10.Protein dynamics.


11.Quantitative structure analysis (e.g. electrostatic calculations).


 

 

Structural bioinformatics entails analysis and prediction of 3D structure of biological macromolecules such as proteins, RNA, and DNA. It deals with generalizations about macromolecular 3D structure such as comparisons of overall folds and local motifs, principles of molecular folding, evolution, and binding interactions, and structure/function relationships, working both from experimentally solved structures and from computational models. This course will provide both a theoretical background on structural bioinformatics and an extensive hands-on experience in using structural bioinformatics methods to assist and direct experimental biology studies. 

 

מבנה הקורס: שעורים (3 ש״ס) ותרגולים (2 ש״ס)

 

 

חובת נוכחות

פרויקט מסכם (עבודה והרצאה)

 

 

1) Introduction to Proteins: Structure, Function, and Motion, 2nd Edition, Amit Kessel, Nir Ben-Tal

2) Structural Bioinformatics, 2nd Edition, Jenny Gu (Editor), Philip E. Bourne (Editor)

3) Introduction to Protein Structure, 2nd Edition, Carl Branden and John Tooze